Job Title: Postdoctoral Associate
The mechanism and novel therapeutic options of obesity-related liver cancer
A postdoctoral position is available in the Fu laboratory in the Department of Medicine at Baylor College of Medicine for a translational research project studying the role of circadian homeostasis in tumor suppression, focusing on obesity-related hepatocellular carcinoma (HCC). The candidates are expected to have training background in molecular and cellular biology and mouse genetics, and good interpersonal skills in teamwork. The project will use state-of-the-art technologies including RNAseq, whole genome sequencing (WGS), ChIP-seq, in vivo nuclear run-on, proteomics and metabolomics as well as gene knock-out, PDX, and humanized mouse models to define the pathophysiological mechanism and therapeutic targets specific to non-alcoholic fatty liver disease (NAFLD)-induced hepatocellular carcinoma (HCC).
1) Working with the PI for hypothesis development and experimental design
2) Performing bench work using various molecular biology techniques and taking the major responsibility in one of the major research projects in the lab
3) Collaborating with clinicians and bioinformaticians in the department and other members in the Fu lab for various research projects.
4) Participating in data processing, discussion, analysis and reporting as well as manuscript preparation and conference presentations.
4) Helping the PI and team in managing the lab.
5) Mentoring junior lab members.
6) Applying fellowships.
A Ph.D. in Basic Science
1) Prior training in molecular biology, mouse genetics and disease models. Especially, the expertise studying mRNA expression, subcellular fragmentation, and protein-protein, protein-RNA, and protein-DNA interactions are preferred.
2) Prior first author publications in peer reviewed journals.
3) A recent Ph.D degree with less than two year experience in post-doctoral training.
3) Highly motivated to pursue an independent career in translational biomedical research.
4) Excellent communication, time management, and teamwork kills.
5) Application documents needed: a cover letter to state research interests, an updated resume, and contact information of minimal three references.